{"id":315,"date":"2023-04-06T18:39:57","date_gmt":"2023-04-06T16:39:57","guid":{"rendered":"https:\/\/neores.se\/?page_id=315"},"modified":"2025-11-28T13:22:43","modified_gmt":"2025-11-28T12:22:43","slug":"the-corsad-trial","status":"publish","type":"page","link":"https:\/\/neores.se\/?page_id=315","title":{"rendered":"The CORSAD Trial"},"content":{"rendered":"<div  data-label=\"Corsad\" data-id=\"about-image-section-pro\" data-category=\"about\" class=\"about-image-section-pro\" id=\"corsad\" style=\"background-color: rgb(255, 255, 255); background-image: none;\" data-ovid=\"ovid-about-us-2-619\"> <div  class=\"gridContainer\"> <div  class=\"row about-image-gridcol-pro\"> <div  class=\"about-image-textcol-pro\" data-type=\"column\"> <h2  class=\"\"> \nCORSAD trial<br ><br >The original trial results were published in JAMA pediatrics by the academic research group in June 2021<\/h2> <img  decoding=\"async\" class=\"custom-image\" src=\"https:\/\/neores.se\/wp-content\/uploads\/2023\/04\/jama_corsad.png\" alt=\"\"><p  class=\"\"> This publication has then been followed by two secondary analysis. The research group has conducted a large multicenter study has been conducted at 7 different neonatal units in five European countries. Mothers at risk of delivery before week 28 were screened and 250 infants were randomized to standard treatment or treatment with rPAP. Of the 246 babies born alive, the mean gestational age was 26 weeks and more than 80% required immediate ventilation. In the delivery room, 55 children treated according to standard care were intubated, while 44 in the rPAP group. The lower delivery room intubation rate with rPAP was statistically significant. Two secondary analyses have been published after the original publication. Neores was not involved in the trial. Thomas Drevhammar is a co-authour with a declared conflict of interest. <\/p> <\/div> <div  data-type=\"column\" class=\"\"><a  class=\"button color1\" href=\"https:\/\/jamanetwork.com\/journals\/jamapediatrics\/fullarticle\/2780513\" target=\"_blank\" data-icon=\"\" rel=\"noopener\">CORSAD in JAMA<\/a>  <\/div> <\/div> <\/div> <\/div><div  data-label=\"Content\" data-id=\"content-image-right\" data-category=\"content\" class=\"content-right-image-section content-image-right\" id=\"content-4\" style=\"background-color: rgb(246, 246, 246);\"> <div  class=\"gridContainer\"> <div  class=\"content-right-image-gridcol\"> <div  class=\"content-right-image-textcol dynamic-color\" data-type=\"column\"> <h2  class=\"\">Post-CORSAD trials<\/h2> <p  class=\"large_text\">The research group has published two manuscripts after the CORSAD trial. A post-hoc subgroup analysis showed that the there were no signs of rPAP group being negatively affected by the reduced intubation rate. Sonja Baldursdottir conducted a BPD follow-up of a cohort. \n<br ><br >A trial, FUIRST, aiming at extended uninterrupted support was completed and intended as a starting point for larger trials on effective transition.<\/p> <a  class=\"button color1\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36627506\" target=\"_blank\" data-icon=\"\"> BPD cohort <\/a> <a  class=\"button color1\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36689927\" target=\"_blank\" data-icon=\"\">Post-hoc analysis<\/a><a  class=\"button color1\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38514168\" target=\"_blank\" data-icon=\"\">FUIRST-trial of a modified rPAP system<\/a><\/div> <div  class=\"content-right-image-imgcol\" data-type=\"column\"> <img  decoding=\"async\" src=\"https:\/\/neores.se\/wp-content\/uploads\/2025\/11\/ec904770-9097-48cc-81c3-f8847e1704ed.jpg\" class=\"\" alt=\"\"> <\/div> <\/div> <\/div> <\/div>","protected":false},"excerpt":{"rendered":"<p>CORSAD trialThe original trial results were published in JAMA pediatrics by the academic research group in June 2021 This publication has then been followed by two secondary analysis. The research group has conducted a large multicenter study has been conducted at 7 different neonatal units in five European countries. Mothers at risk of delivery before&hellip; <br \/> <a class=\"button small blue\" href=\"https:\/\/neores.se\/?p=1\">L\u00e4s mer<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-315","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/neores.se\/index.php?rest_route=\/wp\/v2\/pages\/315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neores.se\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/neores.se\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/neores.se\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neores.se\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=315"}],"version-history":[{"count":15,"href":"https:\/\/neores.se\/index.php?rest_route=\/wp\/v2\/pages\/315\/revisions"}],"predecessor-version":[{"id":2571,"href":"https:\/\/neores.se\/index.php?rest_route=\/wp\/v2\/pages\/315\/revisions\/2571"}],"wp:attachment":[{"href":"https:\/\/neores.se\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}